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This latter property is crucial for formation of zinc fingers and iron-sulfur clusters

[52] A 2013 meta-analysis of 20 different studies concluded that thiamine supplementation can also improve cardiac function in patients with heart failure, [53] which is a great illustration of how energy insufficiency at the cellular level (in the form of ATP deficiency) produces disease in myriad forms

While transient anorectic effects likely contribute to initial weight loss, the sustained reduction in adiposity and the unchanged food intake observed during chronic treatment indicate a dominant role for peripheral energy expenditure

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