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Description
The frequency of MTHFR homozygous genotype 677CC was 89% in the vitamin B-12 group and 85% in the placebo group ( P = 0.18), and the frequency of homozygous 677TT was 0.6% in both groups ( P = 1.00)

Gradually, I felt better and we were on our way

Raises NAD+ and SAM The same study showed that NAD+ and S-adenosyl-methionine (SAM) both went up after NNMT inhibition
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In order to minimise the amount of SAM that is lost in this process, methylcobalamin is today obtained directly in supplements