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Oxygen as a friend and enemy: how to combat the mutational potential of 8-oxo-guanine

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Additionally, metabolite analysis of FDX1-knockout human chronic myelogenous leukemia K562 cells reveals the accumulation of pyruvate and alpha-ketoglutarate in the lipoic acid metabolic pathway, suggesting inhibition of the tricarboxylic acid cycle

In one study, the presence of the rare c2 allele was associated with higher alcohol metabolism in Japanese alcoholics but this effect was only seen at high blood alcohol concentrations
