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Oxygen as a friend and enemy: how to combat the mutational potential of 8-oxo-guanine

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Additionally, metabolite analysis of FDX1-knockout human chronic myelogenous leukemia K562 cells reveals the accumulation of pyruvate and alpha-ketoglutarate in the lipoic acid metabolic pathway, suggesting inhibition of the tricarboxylic acid cycle

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In one study, the presence of the rare c2 allele was associated with higher alcohol metabolism in Japanese alcoholics but this effect was only seen at high blood alcohol concentrations

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