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Li Q, Ren J: Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression

The potential intracellular Ca 2 overload could stem from ATP depletion attributed to defective complex I

However, these positive effects decline with age because the concentration of GHK-Cu in the body decreases with age

Lastly, thorough preclinical and clinical head-to-head studies are needed to carefully explore different types of ferroptosis regulators and determine their therapeutic windows for various cancer types over longer experimental periods, in order to assess efficacy, drug compatibility, drug resistance, and related side effects