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Mechanisms of action Anti-CD38 antibodies exert their therapeutic effects via direct effector mechanisms on MM cells (i.e., CD38 enzymatic inhibition, direct induction of apoptosis) and through Fc-dependent immune mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), complement-directed cytotoxicity (CDC), and antibody-directed cellular phagocytosis (ADCP) (Fig

Research protocols requiring multiple doses over extended timelines should calculate vial sizes to minimize the window between reconstitution and final use

Individual protocols must be personalized based on body composition, metabolic status, and physician assessment