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Chronic niacin deficiency leads to pellagra, a condition now rare in developed countries due to its association with poor nutrition, resulting from low intake of niacin or tryptophan (, , )

Similarly, the aging rats untreated with IGF1 exhibit a significant mitochondrial dysfunction, including reduced activity of ATPase and complex IV (Garcia-Fernandez et al., 2008

Thioredoxin targets of the plant chloroplast lumen and their implications for plastid function
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doi:10.1371/journal.pone.0116967Google Scholar Smith, JL, Lewindon, PJ, Hoskins, AC, et al
