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Similarly, in the current study, DIO mice from both groups that were switched from WD to LD exhibited higher Bacteroidetes and significantly lower Firmicutes relative abundances compared to DIO mice maintained on WD (WD controls

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We also utilized linear regression to examine the mean changes between Weeks 0 and 6 for the two groups

In some embodiments, a formulation described herein further comprises from about 14 to about 17% of a gelling agent (e.g., poloxamer 407), and provides extended sustained release over a period of from about 1 week to about 3 weeks

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