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In vivo studies in rats showed that compared to the free drug, the nanoparticles increased the area under the concentration time curve (AUC) by 2.6 times, prolonged the mean residence time (MRT) by 1.7 times, and the brain drug AUC (0-t) increased from (31.33 6.38) gg -1 h -1 to (45.39 2.08) gg -1 h -1 , significantly improving drug distribution in the central nervous system (Ye et al., 2017)

In contrast to immunosuppressed apoptosis, pyroptosis is characterized by cell expansion until membrane rupture, which results in the release of cytokines and the activation of a cascade of inflammatory and immune responses

Oleic acid (OA) was added to prepare PD-OA and CU-OA

Glutathione can also be taken intravenously

Melatonin Improves Cardiac Function in a Mouse Model of Heart Failure with Preserved Ejection Fraction