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These results suggest that elevations in hippocampal fumarate may contribute to increased antioxidant defenses, which has been previously reported after a 3-week KD [51]

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Despite the development of newer-generation antidepressants with improved pharmacological profiles, challenges related to toxicity, cost, and variable therapeutic response continue to restrict their broader applicability (5)

Results: Fourteen randomized controlled trials (1217 patients) were included in this meta-analysis