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88,89,90 Oxidative stress can modify ATM through cysteine oxidation, phosphorylation, and acetylation, 91 which leads to ATM activation and subsequent phosphorylation of downstream proteins independent of MRN

298,299 The human genome encodes more than 600 E3 ligases, underscoring the vast diversity and specificity of substrates targeted by the UPS

Potential advantages and limitations from a clinical pharmacokinetic perspective

10.1089/ars.2017.7230 3

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