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Paraesthesia is the scientific term for pins and needles

Figure 6 Controversy persists as to whether MS results from initial damage to oligodendrocytes, with a secondary immune response (an inside-out process), or whether autoimmune-induced inflammation causes oligodendrocyte death (an outside-in process) (155)

Elsevier Inc., New York, pp 14 Busquets S, Ametller E, Fuster G, Olivan M, Raab V, Argils JM, Lpez-Soriano FJ (2007) Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model

Int J Mol Sci 15:85915638

Issues such as low bioavailability, complex quality control, and substantial interindividual variability in efficacy remain major obstacles