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In rats, long-term low-dose PS-NPs exposure reduced amygdalar metabolites-N-acetylserotonin, N-acetyl-L-tyrosine, and 4-aminobutyric acid, suggesting impaired neurotransmitter metabolism (Jiang et al., 2023)

They are the first sign of NF-1 and are seen in all children with the condition

doi: 10.1093/jn/130.4.1026S

(Additional file 1: Figure S 1A)
