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Intriguingly, SP and L-car significantly reduced FOXO1 expression in the POI rat model, together with P53 and caspase-3 downregulation

Clinical manifestations range from asymptomatic elevations in serum transaminases to more severe conditions, including cholestatic jaundice, peliosis hepatis, hepatic adenomas, and, in rare cases, hepatocellular carcinoma (75)

Li S, et al

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