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Although functional data supporting a trans- inhibition model were obtained when constitutive activation of JAK2 was shown with a JAK2 construct where the pseudokinase and KDs were swapped and this construct showed significant cytokine-independent activation only in the presence of wild-type JAK2 (51)

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Conversely, bonds CC ( iv ) and C=O ( v ) are found to show opposing trends between each series (Fig

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