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Regulation of the protein disulfide proteome by mitochondria in mammalian cells

The pK a of Tyr9 is 8.1 in the free GST A1-1, but the value increases to 9.2 when glutathione is bound ( a appears dependent on the ionized thiolate, since S-methylglutathione is without effect on the ionization of Tyr9

230 As mentioned earlier, ROS accumulation and associated oxidative stress are important causes of mitochondrial dynamics alterations

The currently accepted explanation for this is the presence of 3 phosphatase and tensin homolog (PTEN) and 5 SH2-containing inositol phosphatase (SHIP)

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