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Nicotine and mood: how nicotine can have both anxiety-inducing and calming effects based on genetics and dosage [25:00]

Garcia-Cardena, G

Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

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Gentle stretches for the wrist flexors and extensors should be performed multiple times daily, especially before and after activities