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Amsterdam, The Netherlands: 1959

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Mechanistic studies indicate that curcumin exerts its therapeutic effects through the complex modulation of various neuroinflammatory signaling cascades, including the nuclear factor kappa-B pathway, NLRP3 inflammasome activation, and nuclear factor erythroid 2-related factor 2-mediated antioxidant responses, while downregulating pro-inflammatory cytokines (such as interleukin-6 and tumor necrosis factor-) and upregulating anti-inflammatory mediators (such as transforming growth factor- and interleukin-10) (Zia et al., 2021