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The activated R-SMADs associate with the related proteins called co-SMADs (e.g

doi: 10.1016/j.foodhyd.2013.09.017 286 RokkaSRantamkiP

Carotenoids may upregulate the activity of antioxidant enzymes, mainly via the activation of the Nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent pathway (Kaulmann and Bohn 2014)

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Free radicals and oxidative stress not only damage proteins but also attack DNA, leading to gene mutations and even cancer
