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212 Mechanistic studies found that, like trans -diamminedichloroplatinum(II), the trans -[PtCl 2 (HN=C(OMe)Me)(NH 3 )] series formed monofunctional adducts that developed into interstrand cross-links between adjacent guanine and cytosine bases

12 Specifically, NAC is thought to affect thioredoxin expression, which regulates DNA binding of NF-kB and glutaredoxin expression that is responsible for detecting changes in the redox state of GSH

Neuronal survival is also linked to the MAPK-CREB signaling pathway

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