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USP7, a deubiquitinating enzyme that acts on HIF-1, mainly plays a regulatory role in the deubiquitination of HIF-1 under hypoxic conditions by mediating epithelial-mesenchymal transformation, tumor invasion, and metastasis in NSCLC [28]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Weerapana E, Wang C, Simon GM, Richter F, Khare S, Dillon MBD, Bachovchin DA, Mowen K, Baker D, Cravatt BF

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