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NAD+ does not carry the same growth-stimulating mechanism and is more broadly applicable across patient profiles, though dosing and delivery method still require clinical judgment

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In the following chapters, we expounded on the molecular mechanisms of pyroptosis, ferroptosis, and autophagy, reviewed their studies in GBM over the last two years, and discussed how to best exploit these pathways to synergistically improve the effect of traditional or novel GBM treatment strategies