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In another multimodal in vivo imaging study, neuromelanin-sensitive MRI assessed LC pigmented neurons, and 11 C-yohimbine PET evaluated central 2-adrenergic receptor density in both PD and HC groups
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An even higher discrepancy exists between the alignments of just the NBD1 + R-domain region (610927) performed to account for domain motions between structures (IFwide to AlphaFold2 model: 2.6 versus 7MPE to AlphaFold2 model: 10.7 )
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