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Importantly, the underlying cell death mechanism is triggered by CBS inhibition in HepG2 cells via ferroptosis, suggesting that CBS has a previously unreported function in this process

Also, those cells use glucose as a source for TCA cycle anaplerosis, which can sufficiently provide -ketoglutarate for glutamate and glutamine synthesis

Phytother Res 34(9):23512365 Hindam MO, Ahmed LA, Sayed NSE, Khattab M, Sallam NA (2024) Repositioning of baricitinib for management of memory impairment in ovariectomized/D-galactose treated rats: a potential role of JAK2/STAT3-PI3K/AKT/mTOR signaling pathway