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Studies show significantly elevated ROS levels and decreased antioxidant defense system function in DW tissues
This mechanism not only ensures targeted drug delivery but also allows for diffusion to adjacent non-targeted cells, resulting in potential bystander effects that enhance therapeutic efficacy [3]

Metabolic crosstalk in the peritumoral niche Disrupting metabolic crosstalk within the glioblastoma peritumoral niche represents a promising frontier in enhancing ferroptosis efficacy
