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Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

Three replicates were performed, and mean percentages were shown

Castori M, Voermans NC

Cholesterol synthesis takes place in the cytosol, and the acetyl-CoA needed can be obtained from several sources such as -oxidation of fatty acids, the oxidation of ketogenic amino acids, such as leucine and lysine, and the pyruvate dehydrogenase reaction (acetyl-CoA shuttled out of the mitochondria is in the form of citrate, which is cleaved into acetyl-CoA and pyruvate by citrate lyase)

G.van der HoltB.ElJ