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While its not totally understood yet how this happens, some researchers theorize it could have something to do with the medications impact on intrinsic factor

Using transmission emission tomography (TEM), the AuTri compounds induced distortions of the mitochondria structure with concomitant time-dependent depletion of mitochondria membrane proteins including, OPA1, MFN1, MFF, and TOM20 by Western blot

People with Asian flush carry a genetic variant (known as ALDH2*2 or rs671) that makes this enzyme work poorly or not at all

doi: 10.3389/fneur.2015.00107 41 BolneoEChauPYSNoakesPGBellinghamMC

Helps inhibit tyrosinase (the enzyme behind melanin production) to reduce dark spots and promote a more even, luminous complexion over timewithout harsh topical treatments or irritation
