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The clinical features strongly resemble classical EDS (cEDS) with two key differences: (1) the absence of atrophic scarring and (2) autosomal recessive inheritance

Vomiting occurs less frequently than nausea but can be problematic when it does occur, particularly if it leads to dehydration or interferes with nutrition and medication absorption

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L-tyrosine and L-dihydroxyphenylalanine (L-DOPA) also serve as substrates and regulators of melanogenesis

Epigenetic mechanisms, encompassing histone modifications, chromatin remodeling, DNA methylation, and non-coding RNA regulation, are increasingly recognized as central to the pathophysiology of endometriosis-related infertility