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Librowski, Curr

Safety Prior to randomization, one patient (of 224 enrolled participants) died, with no relationship between the death and the study or the supplement identified by the CIMATEC committee, since the death occurred prior to collect blood samples or consume the investigational supplement

Additional research is required to identify correlations between plasma TMAO levels and particular genera

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

The UL was established for generally healthy people, and the FNB noted that individuals with liver or kidney disease, Parkinson's disease, depression, or inherited trimethylaminuria might be at increased risk of adverse effects when consuming choline at levels near the UL (32)