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Severe COPD exacerbations resulting in hospitalization can be up to 60-times more expensive than mild or moderate exacerbations managed by primary care services 18 , and every subsequent readmission for COPD costs around 1.5-times more than the index admission 19

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Why: One syringe split between two cheeks offers a subtle highlight

Strategies aimed to increase cytosol GSH (e.g., NAC) may not be an optimal approach for boosting mGSH and therefore for treatment of SH or AD, as it would result in mainly increasing cytosol GSH without replenishing mGSH levels A new approach has been exploited recently in several contexts by the development of a series of cationic antioxidants targeted to mitochondria, including derivatives of the endogenous antioxidants ubiquinol (MitoQ), alpha-tocopherol (MitoVit E), and of the synthetic spin trap PBN (MitoPBN

Studies have revealed a bi-directional link between the lungs and the gut, termed the lung-gut axis (Zhu et al., 2018)