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The formation of 10( E )-9-Hp-12(13)- trans -EpOME from 13( S )-HpODE in the presence of Fe(III)/cysteine has also been reported
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Since NF-kB also regulates RAGE expression, its overexpression causes more AGE binding and, therefore, it forms a feedback loop that activates the inflammatory pathway and the neuronal death (Guerrero et al., 2013)
