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Firstly, cysteine and glutamate form the -glutamylcysteine (GluCys) under the catalysis of the -glutamylcysteine ligase (GCL), then GluCys continues to bind glycine to form GSH under the catalysis of glutathione synthetase (GS)

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Direct polymerization of the arsenic drug PENAO to obtain nanoparticles with high thiol-reactivity and anti-cancer efficiency

In parallel, copper sulfide (CuS) nanoparticles, with strong near-infrared (NIR) absorption and efficient photothermal conversion, can convert NIR light into heat to induce direct tumor ablation

Autosomal dominant disorders (AIP, VP, HCP & PCT)testing of first-degree relatives (parents, siblings and children) is recommended once a diagnosis has been confirmed in someone with symptoms to provide appropriate counseling to family members who may also be at risk of developing symptoms