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doi: 10.17576/jsm-2023-5206-17 45

In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

The impact of these differences on GSH remains to be elucidated

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The precise mechanisms producing atopic dermatitis remain uncertain, while factors such as heredity, immunological responses, and environmental factors have been proposed as potential etiological factors, along with changes in skin barrier function [150]