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Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinsons disease: an open label, phase I trial

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Previous studies have demonstrated that hydrogen gas can inhibit the formation of nitrotyrosine (Zhang et al., 2016), a detectable marker for the indirect measurement of ONOO (Wu et al., 2018), suggesting that hydrogen gas may exert its antioxidant effects by inhibiting ONOO

239 showed that glutathione depletion constitutes one mechanism of ferroptosis