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The same group subsequently published a dose-range study (0.5, 1.0, or 5.0 mg/kg) performed in young mice that underwent transverse aortic constriction (TAC) surgery and reported that although treatment with recombinant GDF11 proteins reduced pathological cardiac hypertrophy and fibrosis and improved cardiac function, the highest dose (5.0 mg/kg) led to severe cachexia and premature death, and they also issued a warning against the use of recombinant GDF11 proteins as a therapy 90

Finkelstein JL, Layden AJ, Stover PJ

Folate (B9)

In research contexts, it is investigated for its roles in skin extracellular matrix (ECM) biology , cellular stress responses , and wound-model dynamics

Patients with severe chronic liver, heart or kidney disease will be assessed by a health Prescriber to determine if they can receive IV therapy and that it does not interfere with any medication