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doi: 10.3389/fonc.2022.858462 Received 21 January 2022 Accepted 04 February 2022 Published 23 February 2022 Volume 12 - 2022 Edited by Puttur Devi Prasad, Augusta University, United States Reviewed by Wolfgang Sadee, The Ohio State University, United States

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Interestingly, hepatocyte growth factor (HGF) induces the expression of GSH synthetic enzymes and acts as a mitogen in liver cancer cells only under subconfluent cell density condition and the mitogenic effect required increased GSH level [29]