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TMAO can inhibit the activation of FXR by changing the size of the bile acid pool, which may weaken or inhibit the beneficial effect of FXR, affect the glucose metabolism of the host, and promote the occurrence and development of insulin resistance and NAFLD

Consistently, we found that depleting KG either through inhibition of wildtype IDH1 or glutamine starvation, or inhibiting KGDD activity via exogenous succinate, sensitized CCNE1-driven cells to DNA damaging agents ( Fig
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