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Peer-reviewed clinical trials in the T4 family (RGN-259 ophthalmic, RGN-352 cardiac) used full-length T4

Serious reactions are extremely rare

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The debate intensified after Karl Landsteiner, an Austrian immunologist at the Rockefeller Institute for Medical Research, demonstrated in a series of experiments in the 1920s that antibodies could bind to haptens, a term he coined to describe synthetic antigens not found in nature