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Exhaustive exercise also increases cytokine expression in the liver, heart, skeletal muscle, and intestines, exacerbating inflammation and tissue damage (157, 184187)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Konjar , Ficht X, Iannacone M & Veldhoen M Heterogeneity of tissue resident memory T cells

Methionine sulfoxide can be subsequently reduced back to methionine by specific reductases, thereby restoring A1ATs functionality and enabling continuous ROS scavenging ( Beside the described scavenging effect, however, oxidation of methionine residues leads to a decrease in the protective effect of A1AT as a protease inhibitor ( For this reason, an increasing number of studies reports the development of engineered forms of A1AT, with amino acid substitution at methionine 351 and 358, designed to keep the anti-protease activity, even in a oxidative microenvironment ( Additionally, the cysteine residues in A1AT may undergo oxidation, which decreases ROS levels

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