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Kumari N, Kaur E, Raghavan SC, Sengupta S

Yes, some individuals experience mild abdominal cramping, bloating, or discomfort when taking vitamin B12 supplements, particularly on an empty stomach or with higher-dose formulations
None of the other ampakines is known to currently be in human trials, so little can be proven about their efficacy or safety in healthy individuals

10.3233/nre-192942 NeuroRehabilitation 84 YangJ

Its definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!).
