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The incorporation of phytochemicals into clinical treatment strategies for MDD presents several promising implications for practice [1]

First, CO exhibits cytoprotective properties in vascular endothelial cells by inhibiting apoptosis, likely through activation of p38 mitogen-activated protein kinase (MAPK) signaling pathway (Brouard et al., 2000), decrease macrophage toll-like receptor (TLR) signaling with downstream activation of NF-kB (Wang et al., 2009) and inhibit expression of GM-CSF with probable alteration of macrophage differentiation (Sarady et al., 2002)

Therefore, it may be more effective to inhibit these ototoxic-inducing pathways together

Then the exhaust is combined with the diesel exhaust fluid (DEF), sent through a final SCR Catalyst to remove NOx, and finally, water and nitrogen are released into the air

Davis, J