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By performing a GWAS in the tirzepatide-treated population alone (Supplementary Table 12), we identified an association between the vomiting side effect and GIPR (rs71338792, P = 4.2 10 9 , odds ratio = 1.84

Too much hydrogen sulfide may also be linked to adrenal insufficiency due to H2S helping to control mitochondrial function in the adrenal tissue (Wang et al., 2014)

A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction