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Characterizations of the GH/IGF-1 axis in numerous animal models have unequivocally shown the importance of this axis in the regulation of skeletal acquisition (Figure 1)

The spacer arm is attached between the ligand and the solid support

However, since the number of non-English articles on the associations between ASD and oxidative stress markers were very limited, and no evidence of publication bias for most analyzed oxidative stress markers, it is unlikely that this would significantly influence our meta-analysis outcome

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