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Within the conceptual framework proposed here, the circadian structure of cortisol secretion represents one component of a broader adaptive system linking neuroendocrine signaling, inflammatory demand, and metabolic regulation

An immunogold labeling assay was performed to examine the association of LOX with CAF sEVs

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Intriguingly, a mild gain-of-function PIEZO1 allele known as E756del is present in one-third of individuals of African descent and is associated with increased plasma iron (70)

Future research should focus on translating these findings into clinical practice through the development of targeted nutritional interventions and pharmacological agents that modulate key metabolic and signaling pathways