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Gnanaraj J, Parnes A, Francis CW, Go RS, Takemoto CM, Hashmi SK
The ideal treatment timing is the early stage of degeneration, when the disc structure is relatively intact (annulus fibrosus not ruptured, endplate not calcified), and functional cells remain
Among experts, a clinically meaningful change in ALSFRS-R in clinical trials would be a reduction of about 20% in the slope of rate of decline [34]
ZeissigSBurgelNGunzelDRichterJMankertzJWahnschaffeUet al
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