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Furthermore, transfecting miR-31 confirmed that miR-31 directly regulates the expression of Foxp3, suggesting that resveratrol targets the Foxp3 signal axis by downregulating the expression of mir-31, regulates the Th17/Treg balance, regulates immunity, maintains inflammation balance, and plays a role in the treatment of UC

When at least 10 studies were available for each treatment against placebo, publication bias and small-study effects were examined visually using the comparison adjusted funnel plot under the fixed-effect model.3 When a funnel plot asymmetry was detected, we performed the Copas selection for the treatment comparisons that were informed by at least 10 studies and for which asymmetry was evident in the funnel plot

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