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D3 mediates the degradation of thyroid hormone since it has only IRD activity

Lipoic acid as an antioxidant: the role of dihydrolipoamide dehydrogenase

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Among these are the (i) production of osmolytes, (ii) removal of the toxic salt ion Na + and Cl or their compartmentalization into vacuoles, and (iii) upregulation of antioxidant mechanisms to eliminate excessive reactive oxygen species (ROS) [5, 7,8,9]

GPX5 is an unusual member of the mammalian GPX family because, unlike the well-known mammalian GPX1-4, it does not contain selenosylcysteine (Secys) at its active site, but instead has cysteine residues (Cys) as its active site (Taylor et al., 2013)