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Importantly, NRF2 regulates the expression of drug transporters and downregulation of NRF2 inhibits the expression of drug transporters and blocks chemoresistance

A well-designed glutathione conjugation strategy considers substrate electrophilicity, the role of the cysteine thiol versus terminal amino or carboxyl groups, protection and deprotection needs, solvent and pH compatibility, oxidation risk, and the downstream analytical question the customer actually needs to answer

On top of being non-invasive, the procedure requires no downtime and is far more cost-effective

Conclusion The findings from this study underscore the critical importance of combining a conductive substrate with electrical stimulation