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Toxicokinetic analysis revealed that rotigotine behenate-PLGA exhibited sustained release, where Cmax and AUC 0 28 d increased proportionally with the dose with moderate accumulation of rotigotine

Specific photosensitizers, such as 4-hydroxyphenyl porphyrin (THOPP), which preferentially accumulate in mitochondria, trigger oxidative damage and enhance apoptotic signaling via caspase-3 activation [140]

45 This environment-sensitive fluorophore exhibits assembly enhanced fluorescence: monomeric probes remain quenched owing to intramolecular charge transfer, whereas PSMA-triggered supramolecular assembly sequesters NBD moieties into hydrophobic nanodomains, restoring fluorescence (Supplementary Fig