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This dysregulation is driven by environmental factors such as cigarette smoke (CS) and amplified by dysregulated expression of molecules including prostaglandin E synthase (PTGES), Hedgehog-interacting protein (HHIP), and hypoxia-inducible factor-1 (HIF-1)forming a vicious cycle of environmental damagemetabolic reprogrammingpathological progression. Aberrant glycolysis in COPD patients serves as a critical metabolic basis for airway remodeling and persistent inflammation

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Exercise lowers hyperleptinemia and restores leptins cardioprotective effects (Lowndes et al., 2014)

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165 Furthermore, an innovative approach involved the development of SLNs co-loaded with quercetin and micro-RNA-150 (mR150), further modified with the asparagine-glycine-arginine peptide for enhanced targeting and functionality
