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In contrast to the positive findings observed with elamipretide, outcomes of trials investigating other agents targeting mitochondrial function or related pathways have been inconsistent

Mol Carcinog 62:12491262 Zou Z, Le Gal K, El Zowalaty A, Pehlivanoglu L, Garellick V, Gul N, Ibrahim M, Bergh P-O, Henricsson M, Wiel C et al (2021) Antioxidants promote intestinal tumor progression in mice

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Bierhaus A., Haslbeck K.-M., Humpert P.M., Liliensiek B., Dehmer T., Morcos M., Sayed A.A.R., Andrassy M., Schiekofer S., Schneider J.G., et al

In patients with diffuse large B-cell lymphoma (DLBCL), elevated PCYT1A expression, accompanied by increased MYC levels and decreased serum PC, correlates with a higher international prognostic index risk classification, suggesting that co-expression of MYC and PCYT1A may serve as a biomarker for disease progression (223)

Additionally, a significant loss of total volumetric density, with a greater impact on the cortical component compared to the contralateral healthy limb, was observed through HR-pQCT